Frequently asked questions

RA is a type of autoimmune disease, where the body’s own immune system mistakenly attacks healthy cells instead of unhealthy one.¹

OTREXUP is a prescription medicine used to treat certain adults with severe, active RA, and children with active polyarticular juvenile idiopathic arthritis (pJIA), after treatment with other medicines including non-steroidal anti-inflammatory drugs (NSAIDs) have been used and did not work well.²

OTREXUP is also used to control the symptoms of severe, resistant, disabling psoriasis in adults when other types of treatment have been used and did not work well.²

OTREXUP should not be used for the treatment of cancer. OTREXUP should not be used for the treatment of children with psoriasis.²

An Otrexup prescription may be filled at either retail or specialty pharmacies, but Otrexup is not usually a stocked item. An advance call to alert the pharmacy of an incoming prescription may encourage the pharmacy to have Otrexup available when you arrive to pick it up. Patients using the Otrexup Co-Pay Assistance Program via their doctors office may indicate their preference for home delivery or pick up at their preferred pharmacy.

Patients with co-pay card questions may call 1-877-853-1312. You can find out your monthly co-pay by calling the number on the back of your insurance card. Otter Pharmaceuticals also offers benefits investigation and prior authorization support through the Otrexup Co-Pay Assistance Program. Ask your doctor if you’re interested in this service.

Yes. Most eligible patients will pay $0* co-pay for their Otrexup each time a prescription is filled. This offer is valid for 13 prescription fills and you must sign up for a new card after your final refill. Certain eligibility restrictions apply.

*Eligibility Restrictions: Offer only valid for patients with commercial prescription insurance. Maximum benefit of up to $250 for each prescription filled. Offer not valid for prescriptions reimbursed under any federal or state healthcare program, including Medicare, Medicaid, or any state medical assistance programs. Offer void where prohibited by law, taxed, or restricted. Offer only valid in the USA. Otter Pharmaceuticals reserves the right to rescind, revoke, or amend this offer at any time without notice. By using this co-pay assistance card, you demonstrate that you understand and agree to comply with the terms and conditions of this offer as put forth on this co-pay assistance card.

This offer is only valid for patients with commercial prescription insurance. Maximum benefit of up to $250 for each prescription filled. Offer not valid for prescriptions reimbursed under any federal or state healthcare program, including Medicare, Medicaid, or any state medical assistance programs. Offer void where prohibited by law, taxed, or restricted. Offer only valid in the USA. Otter Pharmaceuticals reserves the right to rescind, revoke, or amend this offer at any time without notice. By using this co-pay assistance card, you demonstrate that you understand and agree to comply with the terms and conditions of this offer as put forth on this co-pay assistance card.

Otrexup is available in 7 dose strengths²:

Do not take Otrexup if you²:

• are pregnant or planning to become pregnant
• are breastfeeding
• Otrexup can pass into your breast milk and may harm your baby. Do not breastfeed while taking Otrexup. Talk to your doctor about the best way to feed your baby if you take Otrexup
• have alcohol problems (alcoholism)
• have liver problems
• have problems fighting infection (immunodeficiency syndrome)
• have been told you have (or think you have) a blood disorder such as low levels of white blood cells, red blood cells (anemia), or platelets
• have had an allergy to methotrexate or any of the ingredients in Otrexup. See the end of this leaflet for a complete list of ingredients in Otrexup

Talk to your doctor before taking this medicine if you have any of these conditions.

In a clinical study of 101 adult RA patients, 55 and 74 patients reported no or minimal administration-site pain on Day 1 and Day 2, respectively.³

It is important to check the viewing window on the device before administration to inspect for particulates. The window appears yellow prior to injection (unobstructed). After injection, the window is partially blocked with a red shield to indicate that the dose has been given. Please refer to Otrexup’s Instructions For Use. If the viewing window is not blocked at all, call your doctor or pharmacist, or call 1-855-Otrexup (1-855-687-3987) for help. Do not use another Otrexup without talking to your doctor.²

Common side effects of Otrexup include²:

Tell your doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of OTREXUP. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information, including Boxed Warning and Patient Information, at www.otrexup.com/PI.

• Do not drink alcohol while taking Otrexup. Drinking alcohol can increase your chances of getting serious side effects.²
• Otrexup can cause dizziness and tiredness. Do not drive a car, operate machinery, or do anything that needs you to be alert until you know how Otrexup affects you.²
• Certain vaccinations should be avoided while taking Otrexup. Talk to your doctor before you or members of your household receive any vaccines.²

Store Otrexup at room temperature between 68°F to 77°F (20°C to 25°C).²

• Do not freeze
• Keep Otrexup out of the light

Do not throw away in the household trash. Put used Otrexup in an FDA-cleared sharps disposal container right away after use.¹

• If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:
  • made of a heavy-duty plastic
  • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out
  • upright stable during use
  • leak-resistant
  • properly labeled to warn of hazardous waste inside the container
• When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
• Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
• Safely dispose of Otrexup that is out of date or is no longer needed.

For more information, call 1-855-OTREXUP (1-855-687-3987).