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Designed for you - and others with RA

In clinical studies*, a subcutaneous administration of methotrexate (the active ingredient in Otrexup) was shown to have:

JointPain.pngControlled the symptoms of RA significantly better than oral methotrexate2

GItract.pngImproved GI tolerability (nausea, diarrhea, vomiting,  abdominmal pain) compared to taking oral methotrexate1,5,6,7

Otrexup

The Otrexup auto-injector has
 no visible needle and is virtually pain free.3,4,16
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Otrexup can cost as little as $0.
Restrictions Apply.
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*Clinical studies were not performed with Otrexup

† Eligibility Restrictions: Offer only valid for patients with commercial prescription insurance. Maximum benefit of up to $250 for each prescription filled. Offer not valid for prescriptions reimbursed under any federal or state healthcare program, including Medicare, Medicaid, or any state medical assistance programs. Offer void where prohibited by law, taxed, or restricted. Offer only valid in the USA. Antares Pharma, Inc. reserves the right to rescind, revoke, or amend this offer at any time without notice. By using this co-pay assistance card, you demonstrate that you understand and agree to comply with the terms and conditions of this offer as put forth on this co-pay assistance card.

References

1. Rutkowska-Sak L, Rell-Bakalarska M, Lisowska B. Oral vs subcutaneous low-dose methotrexate treatment in reducing gastrointestinal side effects. Reumatologia. 2009;47(4):207-211.
2. Braun J, Kästner P, Flaxenberg P, et al. Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis. Arthritis Rheum. 2008;58(1):73-81.
3. Otrexup [prescribing information]. Ewing, NJ: Antares Pharma Inc.; 2016.
4. Freundlich B, Kivitz A, Jaffe JS. Nearly pain-free self-administration of subcutaneous methotrexate with an autoinjector. J Clin Rheumatol. 2014;20(5):256-260.
5. Dalkilic E, Sahbazlar M, Gullulu M, et al. The time course of gastric methotrexate intolerance in patients with rheumatoid arthritis and psoriatic arthritis. Mod Rheumatol.2013; 23(3):525-528.
6. Wegrzyn J, Adeleine P, Missossec P. Better efficacy of methotrexate given by intramuscular injection than orally in patients with rheumatoid arthritis. Ann Rheum Dis. 2004; 63(10); 1232-1234.
7. Bakker MF, Jacobs JWG, Welsing PMJ, et al. Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study. Ann Rheum Dis. 2010;69 (10): 1849-1852.
16. Data on file. OTX-001. Antares Pharma

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